Decoding the Oncogenic Signals from the Long Non-Coding RNAs
نویسندگان
چکیده
Cancer is one of the leading causes death worldwide. Multifactorial etiology cancer and tumor heterogeneity are two most acute challenges in existing diagnostic therapeutic strategies for cancer. An effective precision medicine strategy to overcome these requires a clear understanding transcriptomic landscape cells. Recent innovative breakthroughs high-throughput sequencing technologies have identified oncogenic or tumor-suppressor role several long non-coding RNAs (lncRNAs). LncRNAs been characterized as regulating various signaling cascades which involved pathobiology They modulate cell survival, proliferation, metabolism, invasive metastasis, stemness, therapy-resistance through their interactions with specific sets proteins, miRNAs other RNAs, mRNAs, DNAs By virtue ability regulate multiple genes cognate pathways, lncRNAs emerging potential candidates diagnostic, prognostic, targets. This review focused on providing insight into mechanisms by different play critical growth, diagnosis, prognosis, therapy.
منابع مشابه
The Role of Long Non-Coding RNAs in Ovarian Cancer
Background: Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. However, the aim of this review was to investigate the role of long non-co...
متن کاملThe Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks
DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous conditions. Such abrasions have deleterious effect in cells leading to genome rearrangements and cell death. A number of repair systems including homologous recombination (HR) and non-homologous end-joining (NHEJ) have been evolved to minimize the fatal effe...
متن کاملthe role of long non-coding rnas in ovarian cancer
background: ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. however, the aim of this review was to investigate the role of long n...
متن کاملLong non-coding RNAs and their significance in human diseases
Protein-coding genes account for only a small fraction of the human genome and most of the genomic sequences are transcriptionally silent, but recent observations indicate significant functional elements, including non-coding protein transcripts in the human genome. Long non-coding RNAs (lncRNAs) have been defined as transcripts of >200 nucleotides without protein-coding capacity that perform t...
متن کاملThe Roles of Long non-coding RNAs (lncRNA) in Prostate Cancer
Background & Objective: Prostate cancer is a compound condition in which gene expression has altered. Several surveys have revealed that genetic components have been involved in prostate cancer progression. Findings proposed that they can modify a noteworthy portion of disposing of elements, which is associated to the developing prostate cancer in protein coding sequences. The purpose of this r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Onco
سال: 2021
ISSN: ['2673-7523']
DOI: https://doi.org/10.3390/onco1020014